The ability of pathogenic bacteria to adapt to the various chemical, biochemical and physical conditions of the different anatomical niches within the human host, as well as an ability to respond to the direct stresses which are generated in these environments, is a central feature of infectious diseases and the outcome of bacterial infection. Our understanding of the mechanisms used by numerous bacteria for this survival, and indeed the nature of the stresses within the human host, has increased significantly over the past 5-10 years. These key aspects of this rapidly developing field will be the central theme of this book. Specifically, it covers: the generation of stresses by the host immune system, the bacterial response to reactive chemicals as a result of the host response to bacterial infection (including reactive oxygen and reactive nitrogen species), bacterial metabolism as part of the stress response and the bacterial adaptation to environmental conditions of anatomical niches such as the gut, mouth and urogenital tract (these conditions include acid conditions, nutrient stress and low oxygen levels), and increasingly, the importance of different metal ions in the pathogenesis and survival of specific bacteria. This volume uses experts in the research of each of these areas to develop a book that provides a comprehensive outline of the current understanding of this field, the latest developments and where future research is likely to be directed
© Copyright 2016. Mohammad Sadegh Adib Sereshki
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